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Poly(ether imide) membranes modified with poly(ethylene imine) as potential carriers for epidermal substitutes.

Authors
  • Trimpert, Christiane
  • Boese, Gregor
  • Albrecht, Wolfgang
  • Richau, Klaus
  • Weigel, Thomas
  • Lendlein, Andreas
  • Groth, Thomas
Type
Published Article
Journal
Macromolecular bioscience
Publication Date
Apr 12, 2006
Volume
6
Issue
4
Pages
274–284
Identifiers
PMID: 16565943
Source
Medline
License
Unknown

Abstract

Poly(ether imide) (PEI) membranes were modified with a linear low-molecular weight (PETIM_0.6) and a branched high-molecular weight poly(ethylene imine) (PETIM_60). The membrane surfaces became more hydrophilic and the zeta potentials were shifted from negative to positive zeta values after immobilisation of both PETIM. These measurements also indicated the presence of a swollen surface layer in the case of PETIM_60, while a regular structuring of the surface was observed with scanning force microscopy for PETIM_0.6. A human keratinocyte cell line HaCaT was cultured on the different membranes. It was found that HaCaT cell growth was stimulated by PETIM_0.6. Cells reached earlier confluence on this substratum, while their growth was inhibited on a PEI membrane modified with PETIM_60, which makes PEI membranes modified with PETIM_0.6 a promising material for in vitro culture of epidermal transplants.

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