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Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives.

Authors
  • Zheng, Maochao1
  • Pan, Miao1
  • Zhang, Wancong2
  • Lin, Huanchang1
  • Wu, Shenlang1
  • Lu, Chao3
  • Tang, Shijie2
  • Liu, Daojun1
  • Cai, Jianfeng4
  • 1 Shantou University Medical College, 22 Xinling Road, Shantou, 515041, China. , (China)
  • 2 The Second Affiliated Hospital of Shantou University Medical College, 69 Dongxiabei Road, Shantou, 515041, China. , (China)
  • 3 College of Pharmacy, Jinan University, Guangzhou, 511443, China. , (China)
  • 4 Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA.
Type
Published Article
Journal
Bioactive Materials
Publisher
KeAi Publishing
Publication Date
Jul 01, 2021
Volume
6
Issue
7
Pages
1878–1909
Identifiers
DOI: 10.1016/j.bioactmat.2020.12.001
PMID: 33364529
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Poly(α-l-lysine) (PLL) is a class of water-soluble, cationic biopolymer composed of α-l-lysine structural units. The previous decade witnessed tremendous progress in the synthesis and biomedical applications of PLL and its composites. PLL-based polymers and copolymers, till date, have been extensively explored in the contexts such as antibacterial agents, gene/drug/protein delivery systems, bio-sensing, bio-imaging, and tissue engineering. This review aims to summarize the recent advances in PLL-based nanomaterials in these biomedical fields over the last decade. The review first describes the synthesis of PLL and its derivatives, followed by the main text of their recent biomedical applications and translational studies. Finally, the challenges and perspectives of PLL-based nanomaterials in biomedical fields are addressed. © 2020 [The Author/The Authors].

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