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Pneumococcal disease during HIV infection. Epidemiologic, clinical, and immunologic perspectives.

Authors
  • Janoff, E N
  • Breiman, R F
  • Daley, C L
  • Hopewell, P C
Type
Published Article
Journal
Annals of Internal Medicine
Publisher
American College of Physicians
Publication Date
Aug 15, 1992
Volume
117
Issue
4
Pages
314–324
Identifiers
PMID: 1637028
Source
Medline
License
Unknown

Abstract

Streptococcus pneumoniae is the leading cause of invasive bacterial respiratory disease in adults and children with HIV infection. Prompt diagnosis and antimicrobial therapy are associated with a favorable clinical outcome. Characterizing the specific immunologic defects associated with invasive pneumococcal disease in HIV-infected patients may facilitate development of successful, cost-effective strategies for prophylaxis.

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