Affordable Access

deepdyve-link
Publisher Website

Pluripotent Stem Cell-Based Organoid Technologies for Developing Next-Generation Vision Restoration Therapies of Blindness.

Authors
  • Singh, Ratnesh K1
  • Binette, Francois1
  • Seiler, Magdalene2, 3, 4, 5
  • Petersen-Jones, Simon M6
  • Nasonkin, Igor O1
  • 1 Lineage Cell Therapeutics, Inc., Alameda, California, USA.
  • 2 Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
  • 3 Department of Physical Medicine & Rehabilitation, University of California, Irvine, Irvine, California, USA.
  • 4 Department of Ophthalmology, University of California, Irvine, Irvine, California, USA.
  • 5 Department of Anatomy & Neurobiology, University of California, Irvine, Irvine, California, USA.
  • 6 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Apr 01, 2021
Volume
37
Issue
3
Pages
147–156
Identifiers
DOI: 10.1089/jop.2020.0016
PMID: 33052761
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Blindness, associated with death of retinal cells at the back of the eye, is caused by a number of conditions with high prevalence such as glaucoma, age-related macular degeneration, and diabetic retinopathy. In addition, a large number of orphan inherited (mostly monogenic) conditions, such as retinitis pigmentosa and Leber Congenital Amaurosis, add to the overall number of patients with blinding retinal degenerative diseases. Blindness caused by deterioration and loss of retina is so far incurable. Modern biomedical research leveraging molecular and regenerative medicine approaches had a number of groundbreaking discoveries and proof-of-principle treatments of blindness in animals. However, these methods are slow to be standardized and commercialized as therapies to benefit people losing their eyesight due to retinal degenerative conditions. In this review, we will outline major regenerative medicine approaches, which are emerging as promising for preserving or/and restoring vision. We discuss the potential of each of these approaches to reach commercialization step and be converted to treatments, which could at least ameliorate blindness caused by retinal cell death.

Report this publication

Statistics

Seen <100 times