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PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.

Authors
  • 1, 2, 3, 4
  • 5
  • 6
  • 7, 8
  • 9
  • 10, 11, 12
  • 13, 14
  • 15
  • 16, 17, 18
  • 19, 20, 21
  • 22
  • 23, 24, 25, 26, 27
  • 28
  • 29, 30
  • 1 a Department of Bioinformatics and Molecular Genetics , Faculty of Biology, University of Freiburg , 79104 Freiburg , Germany.
  • 2 b Department of Pediatrics , Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen , 9713 AV Groningen , The Netherlands.
  • 3 c BIOSS Centre for Biological Signalling Studies, University of Freiburg.
  • 4 d Research Training Group (RTG) 1104, University of Freiburg.
  • 5 b Department of Pediatrics , Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen , 9713 AV Groningen , The Netherlands.
  • 6 b Department of Pediatrics , Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen , 9713 AV Groningen , The Netherlands.
  • 7 e Program of Development, Aging and Regeneration, Sanford Burnham Prebys Medical Discovery Institute , La Jolla , 92037 CA , USA.
  • 8 f Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute , La Jolla , 92037 CA , USA.
  • 9 e Program of Development, Aging and Regeneration, Sanford Burnham Prebys Medical Discovery Institute , La Jolla , 92037 CA , USA.
  • 10 c BIOSS Centre for Biological Signalling Studies, University of Freiburg.
  • 11 g ZBMZ Centre for Biochemistry and Molecular Cell Research (Faculty of Medicine), University of Freiburg.
  • 12 h Institute of Biochemistry and Molecular Biology (Faculty of Medicine), University of Freiburg.
  • 13 i Department of Biochemistry and Functional Proteomics , Faculty of Biology, University of Freiburg.
  • 14 j Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg.
  • 15 a Department of Bioinformatics and Molecular Genetics , Faculty of Biology, University of Freiburg , 79104 Freiburg , Germany.
  • 16 c BIOSS Centre for Biological Signalling Studies, University of Freiburg.
  • 17 i Department of Biochemistry and Functional Proteomics , Faculty of Biology, University of Freiburg.
  • 18 j Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg.
  • 19 c BIOSS Centre for Biological Signalling Studies, University of Freiburg.
  • 20 g ZBMZ Centre for Biochemistry and Molecular Cell Research (Faculty of Medicine), University of Freiburg.
  • 21 h Institute of Biochemistry and Molecular Biology (Faculty of Medicine), University of Freiburg.
  • 22 k Department of Medical Oncology , Cancer Research Center Groningen, University of Groningen, University Medical Center Groningen , 9723 GZ Groningen , The Netherlands.
  • 23 a Department of Bioinformatics and Molecular Genetics , Faculty of Biology, University of Freiburg , 79104 Freiburg , Germany.
  • 24 c BIOSS Centre for Biological Signalling Studies, University of Freiburg.
  • 25 d Research Training Group (RTG) 1104, University of Freiburg.
  • 26 g ZBMZ Centre for Biochemistry and Molecular Cell Research (Faculty of Medicine), University of Freiburg.
  • 27 j Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg.
  • 28 e Program of Development, Aging and Regeneration, Sanford Burnham Prebys Medical Discovery Institute , La Jolla , 92037 CA , USA.
  • 29 b Department of Pediatrics , Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen , 9713 AV Groningen , The Netherlands.
  • 30 l Department for Neuroscience , School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg , 26129 Oldenburg , Germany.
Type
Published Article
Journal
Autophagy
1554-8635
Publisher
Landes Bioscience
Publication Date
Identifiers
DOI: 10.1080/15548627.2016.1263781
PMID: 28102733
Source
Medline
Keywords
  • Bi2536
  • Mtor
  • Mtorc1
  • Plk1
  • Rptor
  • Amino Acid
  • Insulin
  • Interphase
  • Lysosome
  • Starvation

Abstract

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