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Pleomorphic Leiomyosarcoma of the Adrenal Gland in a Young Woman: A Case Report and Review of the Literature

Authors
  • Wang, Yuanyuan1
  • Teng, Yongliang2
  • Na, Shibo3
  • Yuan, Ye1
  • 1 Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin
  • 2 Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin
  • 3 Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, Jilin
Type
Published Article
Journal
OncoTargets and Therapy
Publisher
Dove Medical Press
Publication Date
May 26, 2020
Volume
13
Pages
4705–4713
Identifiers
DOI: 10.2147/OTT.S254162
PMID: 32547099
PMCID: PMC7263850
Source
PubMed Central
Keywords
License
Green

Abstract

Leiomyosarcoma usually arises in the uterus, abdominal and urologic viscera, and walls of large and small blood vessels. However, primary adrenal leiomyosarcoma is extremely rare with only 39 cases previously reported in English-language literature. We report a case of a 29-year-old previously healthy woman with an incidentally found right adrenal-occupying lesion. CT scan revealed a right adrenal mass measuring 3.3×3.4 cm in size. The tumor was successfully removed by laparoscopic adrenalectomy. Postoperative histopathologic examination showed spindle cells arranged in interlacing fascicles with pleomorphism and a high mitotic rate. An immunohistochemical examination showed positive staining for SMA, desmin, vimentin and H-caldesmon, and the diagnosis of a well-differentiated adrenal leiomyosarcoma was established. The patient received no other oncological treatment after surgery and currently has no evidence of residual disease or tumor recurrence according to imaging follow-up.

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