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Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human.

Authors
Type
Published Article
Journal
EMBO Reports
Publisher
EMBO
Publication Date
Nov 01, 2014
Volume
15
Issue
11
Pages
1128–1138
Identifiers
DOI: 10.15252/embr.201438842
PMID: 25252682
Source
Medline
Keywords
License
Unknown

Abstract

The Notch signaling pathway is evolutionarily conserved across species and plays an important role in regulating cell differentiation, proliferation, and survival. It has been implicated in several different hematopoietic processes including early hematopoietic development as well as adult hematological malignancies in humans. This review focuses on recent developments in understanding the role of Notch signaling in the human hematopoietic system with an emphasis on hematopoietic initiation from human pluripotent stem cells and regulation within the bone marrow. Based on recent insights, we summarize potential strategies for treatment of human hematological malignancies toward the concept of targeting Notch signaling for fate regulation.

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