Affordable Access

deepdyve-link
Publisher Website

Pleiotropic effects of prokineticin 2 in the control of energy metabolism.

Authors
  • Magnan, Christophe1
  • Migrenne-Li, Stéphanie2
  • 1 Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France. , (France)
  • 2 Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France. Electronic address: [email protected] , (France)
Type
Published Article
Journal
Biochimie
Publication Date
Apr 29, 2021
Volume
186
Pages
73–81
Identifiers
DOI: 10.1016/j.biochi.2021.04.009
PMID: 33932486
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Prokineticins are family of small proteins involved in many important biological processes including food intake and control of energy balance. The prokineticin 2 (PROK2) is expressed in several peripheral tissues and areas in the central nervous system. PROK2 activates G protein-coupled receptors, namely, prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2). Preclinical models exhibiting disturbances of the PROK2 pathway (at the level of PROK2 or its receptors) are characterized by changes in food intake, feeding behavior and insulin sensitivity related to a dysfunction of the energy balance control. In Humans, mutations of PROK2 and PROKR2 genes are associated to the Kallmann syndrome (KS) that affects both the hormonal reproductive axis and the sense of smell and may also lead to obesity. Moreover, plasma PROK2 concentration has been correlated with various cardiometabolic risk factors and type 2 diabetes (T2D). The present review summarizes knowledge on PROK2 structure, signaling and function focusing on its role in control of food intake and energy homeostasis. Copyright © 2021. Published by Elsevier B.V.

Report this publication

Statistics

Seen <100 times