A sound biological education at early schooling stages is highly desirable for individual understanding of the nature of science and comprehension of evolutionary theory. Making accessible the concepts to young minds is notwithstanding key and playful learning linked to artistic projects can be useful to reach this goal. Here, we propose a set of activities structured into three units that can be developed at school. They use music as a playful learning tool to support students’ motivation to discover the building blocks of genetic code, genetic variation and epigenetic regulation. Familiarity with these core molecular concepts will smooth their future understanding of the evolutionary process. A final activity programmed for a general audience can also contribute to better value scientific knowledge among the local population. And, it will potentially inspire some young girls and boys in orienting their future career development towards science.