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Platelets as a ‘natural factory’ for growth factor production that sustains normal (and pathological) cell biology

Authors
  • Andrade, Sheila Siqueira1
  • de Sousa Faria, Alessandra Valéria2
  • de Paulo Queluz, Dagmar3
  • Ferreira-Halder, Carmen Veríssima2
  • 1 PlateInnove Biotechnology, Avenida Limeira 1131 , (Brazil)
  • 2 Institute of Biology – University of Campinas, UNICAMP, Rua Monteiro Lobato 255 , (Brazil)
  • 3 Piracicaba Dental School, University of Campinas, Avenida Limeira 901 , (Brazil)
Type
Published Article
Journal
Biological Chemistry
Publisher
Walter de Gruyter GmbH
Publication Date
Oct 29, 2019
Volume
401
Issue
4
Pages
471–476
Identifiers
DOI: 10.1515/hsz-2019-0342
Source
De Gruyter
Keywords
License
Yellow

Abstract

Platelets have attracted substantial attention in the current decade owing to their unexpected pleiotropic properties and conflicted functions. In fact, platelets participate in both health (hemostasis) and disease (thrombotic diseases). Much of the plasticity of platelets comes from the fact that platelets are the reservoir and the ‘natural factory’ of growth factors (GFs), with pivotal functions in wound repair and tissue regeneration. By combining the platelets’ plasticity and biotechnological processes, PlateInnove Biotechnology optimized the production of GFs in nanoparticle biointerfacing by platelet content, which opens an avenue of possibilities.

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