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Platelets, complement and tissue inflammation.

Authors
Type
Published Article
Journal
Autoimmunity
1607-842X
Publisher
Informa UK (Taylor & Francis)
Publication Date
Volume
46
Issue
1
Pages
1–5
Identifiers
DOI: 10.3109/08916934.2012.722144
PMID: 22928713
Source
Medline
License
Unknown

Abstract

The release of immunoregulatory and inflammatory molecules following platelet activation has been invariably associated with the expression of tissue injury in several clinical conditions including trauma, organ transplantation, inflammatory bowel diseases and autoimmune diseases. We present a thorough review of the available information on the role of platelets and their interaction with complement cascade on the expression of tissue inflammation and organ damage. We propose that in autoimmune diseases and conditions associated with ischemia/reperfusion, platelets are decorated with complement, become activated and lodge tissues inappropriately to spread the inflammatory process. Interventions such as limiting complement decoration and suppression of signaling processes leading to platelet activation should be met with clinical benefit.

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