Affordable Access

Platelet transfusions in infants with necrotizing enterocolitis.

Authors
  • Fernandes, Caraciolo J
  • O'Donovan, Donough J
Type
Published Article
Journal
Current hematology reports
Publication Date
Mar 01, 2006
Volume
5
Issue
1
Pages
76–81
Identifiers
PMID: 16537050
Source
Medline
License
Unknown

Abstract

Severe thrombocytopenia (< 50 x 10(9)/L) frequently accompanies advanced necrotizing enterocolitis (NEC). In premature infants with severe thrombocytopenia, despite a paucity of evidence to support the practice, platelet transfusions are commonly used to maintain arbitrary levels of platelet counts in an effort to prevent hemorrhage. However, platelet transfusions contain a variety of bioactive factors, including platelet activating factor (PAF), which can augment systemic inflammatory processes. A growing body of evidence that incriminates PAF in the pathogenesis of NEC has emerged over the past few decades from both animal and human data. Both severe thrombocytopenia and multiple platelet transfusions have been associated with increased mortality, but it is admittedly difficult to differentiate between the effects of the underlying disease and the effects, if any, of the platelet transfusions. In this report, we review the roles of PAF and platelet transfusions in infants with severe NEC.

Report this publication

Statistics

Seen <100 times