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Platelet surface glycoprotein changes in patients with cerebral ischemia.

Authors
  • Legrand, C
  • Woimant, F
  • Haguenau, M
  • Caen, J
Type
Published Article
Journal
Nouvelle revue française d'hématologie
Publication Date
Jan 01, 1991
Volume
33
Issue
6
Pages
497–499
Identifiers
PMID: 1818306
Source
Medline
License
Unknown

Abstract

In vitro abnormalities of platelet behaviour have been described in patients with ischemic cerebrovascular disease (ICD) suggesting that changes in platelet receptors and/or platelet a granules may occur in the circulation. We investigated the frequency of such alterations in 95 patients that were studied within a few days after acute stroke. Using specific antibodies to two intrinsic plasma membrane glycoproteins (GPs), the GPIIb-IIIa complex and GPIV, and to thrombospondin (TSP), a a-granular protein that becomes expressed on the platelet surface upon activation, we were able to distinguish two groups of patients: 16 patients presented an increased concentration of TSP on their platelets demonstrating in vivo platelet secretion. These patients could constitute a group with increased risk of thrombosis. In contrast, 20 patients presented a decreased concentration of GPIIb-IIIa and GPIV. This decrease in intrinsic plasma membrane GPs was associated with a decrease in mean platelet volume and may suggest the occurrence of platelet fragmentation in the circulation.

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