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Platelet peripheral benzodiazepine receptors in repeated stress.

Authors
  • Dar, D E
  • Weizman, A
  • Karp, L
  • Grinshpoon, A
  • Bidder, M
  • Kotler, M
  • Tyano, S
  • Bleich, A
  • Gavish, M
Type
Published Article
Journal
Life Sciences
Publisher
Elsevier
Publication Date
Jan 01, 1991
Volume
48
Issue
4
Pages
341–346
Identifiers
PMID: 1846657
Source
Medline
License
Unknown

Abstract

[3H]PK 11195 binding to platelet membranes and plasma stress hormones were studied in soldiers at the beginning of a parachute training course, following 6 days of preparatory exercises, and after the fourth actual parachute jump. A slight reduction (15%; NS) in the number of peripheral benzodiazepine receptors (PBR) was detected at the end of the exercise period, prior to the first jump. Reduced (26%; P less than 0.05) density of PBR was observed immediately after the repeated actual jumps. Equilibrium dissociation constants were not affected by the stressful situation. Plasma cortisol and prolactin levels remained unaltered during the entire study period.

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