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Platelet-derived growth factor stimulates activity of low density lipoprotein receptors.

Authors
  • A Chait
  • R Ross
  • J J Albers
  • E L Bierman
Publication Date
Jul 01, 1980
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Partially purified platelet-derived growth factor stimulates low density lipoprotein binding and degradation in cultured aortic smooth muscle cells of monkeys by increasing the number of available low density lipoprotein receptors. When platelet-derived growth factor was added to quiescent cells, low density lipoprotein binding increased within 4-8 hr. Stimulation of low density lipoprotein receptor activity preceded stimulation of DNA synthesis by platelet-derived growth factor by 8-12 hr. Enhancement of endogenous cholesterol synthesis by platelet-derived growth factor preceded stimulation of low density lipoprotein receptor activity. These findings suggest that the platelet-derived growth factor can increase both the exogenous and endogenous supplies of cholesterol to the cell for its use during cell proliferation.

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