Affordable Access

Platelet-derived growth factor (PDGF) and glial tumorigenesis.

Authors
  • Shih, Alan H
  • Holland, Eric C
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Feb 08, 2006
Volume
232
Issue
2
Pages
139–147
Identifiers
PMID: 16139423
Source
Medline
License
Unknown

Abstract

Platelet-derived growth factor (PDGF) has long been implicated in cancer and is known to be involved in many biological processes. In Central Nervous System (CNS) neoplasms, particularly gliomas, PDGF is often over-expressed. However, what role PDGF plays in tumor progression remains to be fully described. A wide range of work from in vitro studies to mouse models have implicated the PDGF pathway in various processes including proliferation, cellular migration, development, and angiogenesis. Being a secreted factor, PDGF not only has autocrine effects on producing cells but also has potential for paracrine effects on other tumor cells and the tumor microenvironment. The development of small molecules that inhibit the PDGF receptor and various subsequent signaling components promises to introduce new approaches to the treatment of gliomas.

Report this publication

Statistics

Seen <100 times