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Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XIX: 4,4'-Phenylene-bis-sydnone imines.

Authors
  • Rehse, K
  • Kämpfe, M
  • Martens, A
Type
Published Article
Journal
Archiv der Pharmazie
Publication Date
Mar 01, 1993
Volume
326
Issue
3
Pages
163–166
Identifiers
PMID: 8481095
Source
Medline
License
Unknown

Abstract

Fourteen 4,4'-m-phenylene- and two 4,4'-p-phenylene-bis-sydnone imine hydrochlorides have been synthesized. All compounds exhibited good solubility in water. In the m-series the 3-(3-phenylpropyl)-derivative 5c and the 3-hexyl compound 5l showed antiplatelet activities at or below 10 mumol/L (IC50, Born-test with collagen). The corresponding p-compounds had the same (6l) or slightly lower (6c) activity. No effect on the fibrin formation (Quick-test) could be observed.

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