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Plasma and urinary cytokine homeostasis and renal dysfunction during cardiac surgery.

Authors
  • Gormley, S M
  • McBride, W T
  • Armstrong, M A
  • Young, I S
  • McClean, E
  • MacGowan, S W
  • Campalani, G
  • McMurray, T J
Type
Published Article
Journal
Anesthesiology
Publication Date
Nov 01, 2000
Volume
93
Issue
5
Identifiers
PMID: 11046208
Source
Medline
License
Unknown

Abstract

Cardiac surgery using CPB leads to changes in plasma and urinary cytokine homeostasis that correlate with renal proximal tubular dysfunction. This dysfunction may be related to the renal filtration of proinflammatory mediators. Renal autoprotective mechanisms may involve the intrarenal generation of antiinflammatory cytokines.

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