Affordable Access

Plasma lipoproteins as a transport form of extracellular DNA.

Authors
  • Sumenkova, D V1
  • Polyakov, L M
  • Panin, L E
  • 1 Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. [email protected]
Type
Published Article
Journal
Bulletin of experimental biology and medicine
Publication Date
Mar 01, 2013
Volume
154
Issue
5
Pages
622–623
Identifiers
PMID: 23658883
Source
Medline
License
Unknown

Abstract

We showed DNA-binding activity of different classes of plasma lipoproteins in rats and humans. Experiments with fluorescent dye Hoechst 33258 showed that about 12% extracellular plasma DNA is present in circulating lipoproteins complexes; 7-8% of them with HDL. Structural HDL protein apoA-I probably plays the major role in the interaction between extracellular DNA and lipoprotein particle. Participation of lipoproteins in the transport of extracellular DNA can be considered as an important mechanism for elimination of nucleic acids from blood plasma.

Report this publication

Statistics

Seen <100 times