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Plasma lipoproteins in streptozotocin-diabetic rats, after Triton WR-1339 treatment.

Authors
  • Takahashi, K
  • Murase, T
  • Yamada, N
  • Iwamoto, Y
  • Akanuma, Y
  • Takaku, F
Type
Published Article
Journal
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
Publication Date
Dec 01, 1984
Volume
16 Suppl 1
Pages
82–84
Identifiers
PMID: 6532938
Source
Medline
License
Unknown

Abstract

In an attempt to examine whether the VLDL secreted by diabetic rats may be different from that by normal rats, plasma obtained after Triton WR-1339 treatment was analyzed. After Triton treatment, a marked increase in plasma triglyceride levels with lesser increases in cholesterol and phospholipids was observed in both diabetic and control rats. The degree of such increases was almost equal between two groups of rats. The large increases in plasma lipid levels presumably reflect the increase in plasma VLDL fraction. The lipid composition of VLDL of diabetic rats was very similar to that of normal controls. The LDL fraction of diabetic rats was low in its contents of both cholesterol and phospholipids compared with that of normal controls. The composition of IDL and HDL in diabetic rats was similar to that of controls. From these data, we suggest that the VLDL of diabetic rats secreted under basal fasting condition is not different in its lipid composition as well as in amounts from that of controls.

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