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Plasma levels of soluble TNF receptors are associated with cardiac function in patients with Chagas heart disease.

Authors
  • Silva, Whesley Tanor1
  • Costa, Henrique Silveira2
  • Lima, Vanessa Pereira de2
  • Xavier, Diêgo Mendes1
  • Mendonça, Vanessa Amaral2
  • Lacerda, Ana Cristina Rodrigues2
  • Lage, Vanessa Kelly da Silva3
  • Lima, Márcia Maria Oliveira1
  • Rocha, Manoel Otávio Costa4
  • Figueiredo, Pedro Henrique Scheidt5
  • 1 Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil. , (Brazil)
  • 2 Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil; Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil. , (Brazil)
  • 3 Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil. , (Brazil)
  • 4 Programa de Pós-Graduação em Doenças Infeciosas e Medicina Tropical, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. , (Brazil)
  • 5 Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil; Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
International journal of cardiology
Publication Date
Oct 01, 2020
Volume
316
Pages
101–103
Identifiers
DOI: 10.1016/j.ijcard.2020.04.053
PMID: 32320786
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The soluble receptors tumor necrosis factor-alpha (sTNFRs) can lead to an increase in the expression of tumor necrosis factor, increasing its detrimental to systemic inflammatory activation in Chagas cardiomyopathy (ChC). However, the correlation between sTNFRs levels, echocardiographic, and functional levels in patients with ChC remains unknown. This study aimed to verify the correlation between the plasma sTNFRs levels, echocardiographic, and NYHA functional levels in patients with ChC. Sixty-four patients with ChD (54 ± 2 years, 44% males, NYHA I-II) were evaluated by anamnesis protocol, echocardiography, and plasma sTNFR1 and sTNFR2 measurement. Linear regression analysis and Student's t-test were used as appropriate. Higher plasma sTNFR1 and sTNFR2 levels were associate with worse systolic function (R2 = 0.10; p = 0.008 and R2 = 0.44; p < 0.001) and cardiac dilation (R2 = 0.13; p = 0.002 and R2 = 0.43; p < 0.001). Patients with systolic dysfunction and cardiac dilatation had higher sTNFRs levels (p < 0.001). There were no significant differences among NYHA functional classes for both sTNFRs. Plasma sTNFR1 and sTNFR2 levels are associated with greater cardiac dilation and poor systolic function in ChC patients. Copyright © 2020 Elsevier B.V. All rights reserved.

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