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[Plasma levels of fosfestrol and its monophosphate, of diethylstilbestrol and its monoglucuronide following intravenous administration in patients with metastatic prostatic carcinoma].

Authors
  • Oelschläger, H
  • Rothley, D
  • Dunzendorfer, U
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Jan 01, 1984
Volume
34
Issue
10
Pages
1333–1336
Identifiers
PMID: 6542793
Source
Medline
License
Unknown

Abstract

A homogeneous ion pair extraction technique enables the nearly quantitative isolation of fosfestrol (1) (Honvan) and up till now of three of its metabolites from the plasma of patients suffering from metastatic prostata cancer. The detection occurs by HPLC with UV-detector. The range of detection is in the lower microgram range. It is the first time that plasma levels of 1 and its monophosphate (2) can be measured.

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