Affordable Access

Plasma immunoreactive beta-endorphin levels in depression. Effect of electroconvulsive therapy.

Authors
  • Alexopoulos, G S
  • Inturrisi, C E
  • Lipman, R
  • Frances, R
  • Haycox, J
  • Dougherty, J H Jr
  • Rossier, J
Type
Published Article
Journal
Archives of General Psychiatry
Publisher
American Medical Association
Publication Date
Feb 01, 1983
Volume
40
Issue
2
Pages
181–183
Identifiers
PMID: 6297423
Source
Medline
License
Unknown

Abstract

Immunoreactive (ir) plasma beta-endorphin level was assayed in ten symptomatic patients with a unipolar major depressive disorder and in 16 psychiatrically normal controls matched for age and sex. Plasma ir-beta-endorphin level in depressed patients was similar to that in controls. All depressed patients was similar to that in controls. All depressed patients had a transient, approximately threefold increase in ir-beta-endorphin after each use of electroconvulsive therapy (ECT). The increase of plasma ir-beta-endorphin level after ECT parallels the transient elevation of adrenocorticotropic hormone level reported by others and probably reflects a hypothalamic response to ECT.

Report this publication

Statistics

Seen <100 times