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Plasma immunoreactive beta-endorphin levels in depression. Effect of electroconvulsive therapy.

Authors
Type
Published Article
Journal
Archives of General Psychiatry
0003-990X
Publisher
American Medical Association
Publication Date
Volume
40
Issue
2
Pages
181–183
Identifiers
PMID: 6297423
Source
Medline
License
Unknown

Abstract

Immunoreactive (ir) plasma beta-endorphin level was assayed in ten symptomatic patients with a unipolar major depressive disorder and in 16 psychiatrically normal controls matched for age and sex. Plasma ir-beta-endorphin level in depressed patients was similar to that in controls. All depressed patients was similar to that in controls. All depressed patients had a transient, approximately threefold increase in ir-beta-endorphin after each use of electroconvulsive therapy (ECT). The increase of plasma ir-beta-endorphin level after ECT parallels the transient elevation of adrenocorticotropic hormone level reported by others and probably reflects a hypothalamic response to ECT.

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