Affordable Access

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

  • de Carvalho, Leonardo P.
  • Tan, Sock Hwee
  • Ow, Ghim-Siong
  • Tang, Zhiqun
  • Ching, Jianhong
  • Kovalik, Jean-Paul
  • Poh, Sock Cheng
  • Chin, Chee-Tang
  • Richards, A. Mark
  • Martinez, Eliana C.
  • Troughton, Richard W.
  • Fong, Alan Yean-Yip
  • Yan, Bryan P.
  • Seneviratna, Aruni
  • Sorokin, Vitaly
  • Summers, Scott A.
  • Kuznetsov, Vladimir A.
  • Chan, Mark Y.
Publication Date
May 30, 2018
PubMed Central
External links


We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature’s 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.

Report this publication


Seen <100 times