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Plasma and cellular pharmacokinetic considerations for the development and optimization of antitumor block copolymer micelles.

Authors
  • Zhang, Jingwei
  • Liu, Jiali
  • Zhao, Yanlei
  • Wang, Guangji
  • Zhou, Fang
Type
Published Article
Journal
Expert Opinion on Drug Delivery
Publisher
Informa UK (Taylor & Francis)
Publication Date
Feb 01, 2015
Volume
12
Issue
2
Pages
263–281
Identifiers
DOI: 10.1517/17425247.2014.945417
PMID: 25217414
Source
Medline
Keywords
License
Unknown

Abstract

Different strategies and designs of BCMs can help solve problems in each key step respectively. However, overemphasis on one aspect will result in problems on others. Therefore, a comprehensive consideration is urgently needed to integrate the advantages of each strategy and overcome the disadvantages. Only with thorough understanding and scientific assessments, the desired BCMs are expected to be applied in clinical treatments.

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