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Plasma catecholamine metabolites as markers for psychosis and antipsychotic response in schizophrenia.

Authors
  • Kelley, M E
  • Yao, J K
  • van Kammen, D P
Type
Published Article
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Publication Date
Jun 01, 1999
Volume
20
Issue
6
Pages
603–611
Identifiers
PMID: 10327429
Source
Medline
License
Unknown

Abstract

The objective of this study was to determine the association between the patterns of change in the dopaminergic metabolite plasma homovanillic acid (HVA), the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), and psychosis following haloperidol withdrawal in schizophrenic patients. Weekly plasma measurements were obtained in 107 subjects with schizophrenia or schizoaffective disorder. Random regression was used to control for individual variance while modeling metabolite changes over time and relationships with psychosis. Changes in plasma MHPG were not significantly associated with relapse or psychosis, while increased plasma HVA was found to be associated with relapse. Psychosis was correlated negatively with plasma HVA levels. The current analysis, controlling for individual variance, indicates that there is evidence for pharmacological effects on plasma HVA, but not plasma MHPG. In addition, these metabolites do not appear to be direct markers of psychosis, but may be associated with a compensatory response by the system to return to the steady state.

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