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Plant-Derived Natural Compounds for the Treatment of Amyotrophic Lateral Sclerosis: An Update.

Authors
  • Mohi-Ud-Din, Roohi1
  • Mir, Reyaz Hassan2
  • Shah, Abdul Jalil2
  • Sabreen, Saba2
  • Wani, Taha Umair3
  • Masoodi, Mubashir Hussain2
  • Akkol, Esra Küpeli4
  • Bhat, Zulfiqar Ali1
  • Khan, Haroon5
  • 1 Pharmacognosy & Phytochemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, 190006, Kashmir,India. , (India)
  • 2 Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir,India. , (India)
  • 3 Pharmaceutics Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir,India. , (India)
  • 4 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara,Turkey. , (Turkey)
  • 5 Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200,Pakistan. , (Pakistan)
Type
Published Article
Journal
Current neuropharmacology
Publication Date
Jan 01, 2022
Volume
20
Issue
1
Pages
179–193
Identifiers
DOI: 10.2174/1570159X19666210428120514
PMID: 33913406
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that typically causes death within 3-5 years after diagnosis. Regardless of the substantial scientific knowledge accrued more than a century ago, truly effective therapeutic strategies remain distant. Various conventional drugs are being used but are having several adverse effects. The current study aims to thoroughly review plant-derived compounds with welldefined ALS activities and their structure-activity relationships. Moreover, the review also focuses on complex genetics, clinical trials, and the use of natural products that might decrypt the future and novel therapeutics in ALS. The collection of data for the compilation of this review work was searched in PubMed Scopus, Google Scholar, and Science Direct. Results showed that phytochemicals like-Ginkgolides, Protopanaxatriol, Genistein, epigallocatechingallate, resveratrol, cassoside, and others possess Amyotrophic lateral sclerosis (ALS) activity by various mechanisms Conclusion: These plant-derived compounds may be considered as supplements for conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structureactivity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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