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The plant pathogen Pectobacterium atrosepticum contains a functional formate hydrogenlyase‐2 complex

Authors
  • Finney, Alexander J.1, 2
  • Lowden, Rebecca2
  • Fleszar, Michal2
  • Albareda, Marta2, 3, 3
  • Coulthurst, Sarah J.2
  • Sargent, Frank1, 2
  • 1 Newcastle University, UK , (United Kingdom)
  • 2 University of Dundee, UK , (United Kingdom)
  • 3 Universidad Politécnica de Madrid, Spain , (Spain)
Type
Published Article
Journal
Molecular Microbiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 10, 2019
Volume
112
Issue
5
Pages
1440–1452
Identifiers
DOI: 10.1111/mmi.14370
PMID: 31420965
PMCID: PMC7384014
Source
PubMed Central
License
Unknown
External links

Abstract

Pectobacterium atrospecticum contains the genes for formate hydrogenlyase‐2, considered the ancient progenitor of Complex I. Here, P. atrosepticum was harnessed as a new model system for advancing new knowledge in FHL‐2. The complex was found to contain an unusual selenium‐free formate dehydrogenase and a [NiFe]‐hydrogenase‐4 with a large membrane arm. FHL‐2 was established as the major source of hydrogen gas; however, some components of the membrane arm were surprisingly not essential for this activity.

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