Affordable Access

Publisher Website

Plant Antimicrobial Peptides: State of the Art, In Silico Prediction and Perspectives in the Omics Era

  • dos Santos-Silva, Carlos André1
  • Zupin, Luisa2
  • Oliveira-Lima, Marx1
  • Vilela, Lívia Maria Batista1
  • Bezerra-Neto, João Pacifico1
  • Ferreira-Neto, José Ribamar1
  • Ferreira, José Diogo Cavalcanti1, 3
  • de Oliveira-Silva, Roberta Lane1
  • Pires, Carolline de Jesús1
  • Aburjaile, Flavia Figueira1
  • de Oliveira, Marianne Firmino1
  • Kido, Ederson Akio1
  • Crovella, Sergio2, 4
  • Benko-Iseppon, Ana Maria1
  • 1 Departamento de Genética, Universidade Federal de Pernambuco, Recife, Brazil
  • 2 Genetic Immunology laboratory, Institute for Maternal and Child Health—IRCCS, Burlo Garofolo, Trieste, Italy
  • 3 Departamento de Genética, Instituto Federal de Pernambuco, Pesqueira, Brazil
  • 4 Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy
Published Article
Bioinformatics and Biology Insights
"Libertas Academica, Ltd."
Publication Date
Sep 02, 2020
DOI: 10.1177/1177932220952739
PMID: 32952397
PMCID: PMC7476358
PubMed Central


Even before the perception or interaction with pathogens, plants rely on constitutively guardian molecules, often specific to tissue or stage, with further expression after contact with the pathogen. These guardians include small molecules as antimicrobial peptides (AMPs), generally cysteine-rich, functioning to prevent pathogen establishment. Some of these AMPs are shared among eukaryotes (eg, defensins and cyclotides), others are plant specific (eg, snakins), while some are specific to certain plant families (such as heveins). When compared with other organisms, plants tend to present a higher amount of AMP isoforms due to gene duplications or polyploidy, an occurrence possibly also associated with the sessile habit of plants, which prevents them from evading biotic and environmental stresses. Therefore, plants arise as a rich resource for new AMPs. As these molecules are difficult to retrieve from databases using simple sequence alignments, a description of their characteristics and in silico (bioinformatics) approaches used to retrieve them is provided, considering resources and databases available. The possibilities and applications based on tools versus database approaches are considerable and have been so far underestimated.

Report this publication


Seen <100 times