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Planar optofluidic chip for single particle detection, manipulation, and analysis.

Authors
Type
Published Article
Journal
Lab on a Chip
Publisher
The Royal Society of Chemistry
Volume
7
Issue
9
Pages
1171–1171
Source
UCSC Bioengineering biomedical-ucsc
License
Unknown

Abstract

We present a fully planar integrated optofluidic platform that permits single particle detection, manipulation and analysis on a chip. Liquid-core optical waveguides guide both light and fluids in the same volume. They are integrated with fluidic reservoirs and solid-core optical waveguides to define sub-picoliter excitation volumes and collect the optical signal, resulting in fully planar beam geometries. Single fluorescently labeled liposomes are used to demonstrate the capabilities of the optofluidic chip. Liposome motion is controlled electrically, and fluorescence correlation spectroscopy (FCS) is used to determine concentration and dynamic properties such as diffusion coefficient and velocity. This demonstration of fully planar particle analysis on a semiconductor chip may lead to a new class of planar optofluidics-based instruments.

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