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Placebo Oral Rabies Vaccine Bait Uptake by Small Indian Mongooses (Herpestes auropunctatus) in Southwestern Puerto Rico.

Authors
  • Berentsen, Are R1
  • Chipman, Richard B2
  • Nelson, Kathleen M2
  • Gruver, Kenneth S3
  • Boyd, Frank4
  • Volker, Steven F1
  • Davis, Amy J1
  • Vos, Ad5
  • Ortmann, Steffen5
  • Gilbert, Amy T1
  • 1 US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 LaPorte Ave., Fort Collins, Colorado, 80521, USA.
  • 2 US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Rabies Management Program, 59 Chenell Dr., Suite 2, Concord New Hampshire 03301, USA.
  • 3 US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, 602 Duncan Dr., Auburn, Alabama 36849, USA.
  • 4 Frank Boyd, LLC, 1242 Pinebrook Cir., Auburn, Alabama 36830, USA.
  • 5 Ceva Santé Animale, Am Pharmapark, 06846 Dessau-Rosslau, Germany. , (Germany)
Type
Published Article
Journal
Journal of wildlife diseases
Publication Date
Nov 21, 2019
Identifiers
PMID: 31750771
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The small Indian mongoose (Herpestes auropunctatus) is a rabies reservoir in areas of the Caribbean including Puerto Rico, but no rabies vaccination program targeting this host exists. We used two derivatives of iophenoxic acid (IPA) to evaluate placebo oral rabies vaccine bait uptake by mongooses in southwestern Puerto Rico. We hand-distributed baits at an application rate of 200 baits/km2 at three, 400 ha, sites during autumn 2016 and spring 2017. Each site contained 90-100 cage traps in a 100 ha central trapping area. We used ethyl-IPA as a biological marker during the autumn and methyl-IPA during the spring. We live captured mongooses for 10 consecutive days, beginning 1 wk following bait application. We obtained a serum sample from captured mongooses and analyzed the sera for ethyl- and methyl-IPA by liquid chromatography-mass spectrometry. During autumn 2016, 63% (55/87) mongooses sampled were positive for ethyl-IPA. In spring 2017, 69% (85/123) of mongooses were positive for methyl-IPA. Pooling seasons, accounting for recaptures between years, and disregarding marker type, 74% (133/179) unique mongooses were positive for IPA biomarker, indicating bait consumption during either the autumn, spring, or both trials. We conclude that distributing baits at an application rate of 200 baits/km2 is sufficient to reach over 60% of the target mongoose population in dry forest habitats of Puerto Rico.

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