We review the research over the past decade on the subject of the Placebo Neurochemical mechanism, and it's random presence in the clinic. Our goal is to present the scientific basis of the placebo, and to arouse the awareness of physicians and scientists to the crucial role of placebo in medicine and pharmacological research. The modeling of rationality in modern times displaced the placebo issue to the sidelines of consensus, and it was only around 1950 that scientific interest in the phenomenon reawakened. Today the existence of a Placebo Effect is not doubted--not in everyone, and not at all times, but it's existence is not doubted in relation to groups of people throughout their lives. The involvement of a neurochemical mechanism in the Placebo Effect is also supported by the literature presented, and chemicals such as CCK, Naloxone, Proglumide, and Endorphins seem to effect the neuronal webs mediating the Analgestic Placebo Effect.