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PKC inhibition results in a Kv 1.5 + Kv β1.3 pharmacology closer to Kv 1.5 channels.

Authors
  • Macías, A1
  • de la Cruz, A
  • Prieto, A
  • Peraza, D A
  • Tamkun, M M
  • González, T
  • Valenzuela, C
  • 1 Modelos Experimentales Enfermedades Humanas, Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM), Madrid, Spain. , (Spain)
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2014
Volume
171
Issue
21
Pages
4914–4926
Identifiers
DOI: 10.1111/bph.12822
PMID: 24946104
Source
Medline
License
Unknown

Abstract

The finding that the voltage-dependence of inactivation and the pharmacology of Kv 1.5 + Kv β1.3 channels after PKC inhibition resembled that observed in Kv 1.5 channels suggests that both processes are dependent on PKC-mediated phosphorylation. These results may have clinical relevance in diseases that are characterized by alterations in kinase activity.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 06/09/2018 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/24946104
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