Affordable Access

Pipecolic acid receptors in rat cerebral cortex.

Authors
  • Charles, A K
Type
Published Article
Journal
Neurochemical research
Publication Date
Apr 01, 1986
Volume
11
Issue
4
Pages
521–525
Identifiers
PMID: 3014361
Source
Medline
License
Unknown

Abstract

Identification of [14C]pipecolic acid (PA) receptors was attempted in the solubilized membrane fraction from rat cerebral cortex. Specific binding proteins for both PA and muscimol, a potent gamma-aminobutyric acid (GABA) agonist, were detected in the same preparation. Separation of labeled PA and GABA binding proteins by glycerol gradient centrifugation has shown labeled protein bands of similar sedimentation rates, suggesting that PA and GABA may be binding to identical proteins. It seems likely that the PA binding receptor either may possess the same sedimentation characteristics as that of the GABA receptor, or both GABA and PA which is an endogenous and weak GABA agonist may bind to the same receptor complex, if not to the same binding site.

Report this publication

Statistics

Seen <100 times