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Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells.

Authors
  • Koo, K A
  • Lee, M K
  • Kim, S H
  • Jeong, E J
  • Kim, S Y
  • Oh, T H
  • Kim, Y C
Type
Published Article
Journal
British journal of pharmacology
Publication Date
Jan 01, 2007
Volume
150
Issue
1
Pages
65–71
Identifiers
PMID: 17143305
Source
Medline
License
Unknown

Abstract

These results show that pinusolide and 15-MPA protect neuronal cells from STS-induced apoptosis, probably by preventing the increase in [Ca(2+)]i and cellular oxidation caused by STS, and indicate that they could be used to treat neurodegenerative diseases.

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