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PIM3-AMPK-HDAC4/5 axis restricts MuERVL-marked 2-cell-like state in embryonic stem cells

Authors
  • Zhao, Xin
  • Shen, Jian
  • Zhao, Xuan
  • Zhang, Miao
  • Feng, Xiao
  • Zhang, Weiyu
  • Lu, Xinyi
Type
Published Article
Journal
Stem Cell Reports
Publisher
Elsevier
Publication Date
Sep 22, 2022
Volume
17
Issue
10
Pages
2256–2271
Identifiers
DOI: 10.1016/j.stemcr.2022.08.009
PMID: 36150380
PMCID: PMC9561635
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Zhao et al. discover the PIM3 signaling pathway as a key route to repress MuERVL and 2-cell-like totipotent state in ESCs. Pim3 loss allows phosphorylation of AMPK, which phosphorylates HDAC4/5 and promotes their transport out of the nucleus, thereby permitting acetylation of H3K9 and interfering with H3K9me1/2 deposition on MuERVL. Their findings provide a novel strategy to activate 2-cell-like totipotency.

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