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PILRα negatively regulates mouse inflammatory arthritis.

Authors
  • Sun, Yonglian
  • Caplazi, Patrick
  • Zhang, Juan
  • Mazloom, Anita
  • Kummerfeld, Sarah
  • Quinones, Gabriel
  • Senger, Kate
  • Lesch, Justin
  • Peng, Ivan
  • Sebrell, Andrew
  • Luk, Wilman
  • Lu, Yanmei
  • Lin, Zhonghua
  • Barck, Kai
  • Young, Judy
  • Del Rio, Mariela
  • Lehar, Sophie
  • Asghari, Vida
  • Lin, WeiYu
  • Mariathasan, Sanjeev
  • And 11 more
Type
Published Article
Journal
The Journal of Immunology
Publisher
The American Association of Immunologists
Publication Date
Jul 15, 2014
Volume
193
Issue
2
Pages
860–870
Identifiers
DOI: 10.4049/jimmunol.1400045
PMID: 24935926
Source
Medline
License
Unknown

Abstract

Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα with anti-PILRα mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRα mediates an important inhibitory pathway that can dampen inflammatory responses.

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