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Pilot study of ambulatory infusional delivery of a multidrug regimen: cisplatin, 5-fluorouracil and leucovorin (PFL) +/- etoposide.

Authors
  • Lokich, J
  • Anderson, N
  • Moore, C
  • Bern, M
  • Coco, F
  • Dow, E
  • Zipoli, T
  • Gonzalves, L
Type
Published Article
Journal
The Journal of infusional chemotherapy
Publication Date
Jan 01, 1996
Volume
6
Issue
1
Pages
43–46
Identifiers
PMID: 8748007
Source
Medline
License
Unknown

Abstract

Ambulatory infusional PLF with carboplatin or cisplatin using sequentially alternating delivery of the component antineoplastic agents is feasible and active with minimal toxicity. The addition of infusional etoposide to the PLF regimen does not substantially increase hematologic toxicity. Extended phase II studies in aerodigestive cancers are ongoing and a phase III trial comparing this ambulatory regimen to short-term PLF infusion (5-day) may be justified to compare the relative cost and benefits of the two schedules.

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