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Picture perfect: DNA-templated photoaffinity labeling.

Authors
  • Barluenga, Sofia
  • Winssinger, Nicolas
Type
Published Article
Journal
ChemBioChem
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 11, 2013
Volume
14
Issue
15
Pages
1927–1928
Identifiers
DOI: 10.1002/cbic.201300416
PMID: 24006240
Source
Medline
Keywords
License
Unknown

Abstract

Just so far apart and no further: Small molecules target ID by DNA tagging. Nucleic acid hybridization has been used to pair a photo-crosslinking group with a small molecule of interest. Following photoactivation, the protein(s) interacting with the small molecule are covalently linked to a nucleic acid tag.

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