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Phytoestrogens inhibit key-enzymes linked to obesity, type 2 diabetes and liver-kidney toxicity in high fructose-fat diet in mice.

Authors
  • Hamden, Khaled1
  • Boujibiha, Mohamed Ali1
  • Ben Abdeljelil, Nouha2
  • Njima, Manel2
  • Selmi, Boulbaba1
  • Achour, Lotfi1
  • 1 Laboratory of Bioresources: Integrative Biology and Valorisation, Higher Institute of Biotechnology of Monastir, University of Monastir , Monastir , Tunisia. , (Tunisia)
  • 2 Laboratory of Histology-Pathology, CHU Fattoma Bourguiba, University of Monastir , Monastir Tunisia. , (Tunisia)
Type
Published Article
Journal
Archives of physiology and biochemistry
Publication Date
Dec 01, 2019
Volume
125
Issue
5
Pages
423–429
Identifiers
DOI: 10.1080/13813455.2018.1479427
PMID: 29898610
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Objective: To evaluate the effect of the administration of phytoestrogens on obesity, type 2 diabetes, and liver-kidney toxicity. Methods: Phytoestrogens (phyto(E2)) were administrated to high fructose-fat diet (HFFD). Results: This study showed that administration of phyto(E2) to HFFD-mice inhibited lipase activity by 34%, decreased body weight by 20% and modulated lipid profile, showed a decrease in total-cholesterol (TC) and LDL-cholesterol (LDL-C) rates in the plasma by 59% and 42%, respectively, and increased the HDL-cholesterol (HDL-C) level by 31%. In addition, the administration of phytoestrogens to HFFD-mice exerts an inhibitory effect on α-amylase activity and decreased glucose level by 28% and increase in liver glycogen level by 33%; and ameliorate oral glucose tolerance test. Conclusions: This study demonstrate that phyto(E2) has both a promising potential with regards to the inhibition of intestinal lipase and α-amylase activities, and a valuable hypoglycemic and hypolipidemic function.

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