Punica peel has been used for thousands of years to cure a wide range of diseases across different cultures and civilizations. It has great nutritional values and numerous health benefits. This study was carried out to investigate phytochemical classes, and to evaluate antimicrobial and antioxidant potential of punica grantum peel. The phytochemical screening showed presence of alkaloid, flavonoids, tannins, steroid, triterpenes, saponin and sterol. The antibacterial activity was high for punica ethanol extract with inhibition zone (30mm) against Staphylococcus aureus. The antifungal activity was high for punica methanolic extract against Candida albicans with inhibition zone (22mm). The three punica grantum peel extracts showed good antioxidant activity using DPPH radical a scavenging activity method.