Affordable Access

deepdyve-link
Publisher Website

The physiopathology of avascular necrosis of the femoral head: an update.

Authors
  • Guerado, Enrique1
  • Caso, Enrique2
  • 1 Department of Orthopaedic Surgery and Traumatology, Hospital Universitario Costa del Sol. University of Malaga, Spain. Electronic address: [email protected]
  • 2 Research Unit, Hospital Universitario Costa del Sol. University of Malaga, Spain.
Type
Published Article
Journal
Injury
Publication Date
December 2016
Volume
47 Suppl 6
Identifiers
DOI: 10.1016/S0020-1383(16)30835-X
PMID: 28040082
Source
Medline
Keywords
License
Unknown

Abstract

The physiopathology of the femoral head bone necrosis is similar for children and for adults. The disease is characterized by apoptosis of bone cells - bone marrow and bone forming cells-resulting in head collapse with a subsequent lesion of the overlying cartilage, and therefore flattening of the rounded surface shape of the head articulating with the acetabulum, provoking, eventually, secondary osteoarthritis. When the disease becomes clinically evident already destructive phenomena have occurred and collapse will eventually ensue. In children, because epiphyseal cartilage has growth capabilities, lost epiphyseal height can be recovered, however in adults collapse is irreversible. In this paper the physiopathology of this disease is examined as well as its implication for treatment. Prevention by genetic studies is discussed.

Report this publication

Statistics

Seen <100 times