Affordable Access

Access to the full text

Physiology of guanosine-based second messenger signaling in Bacillus subtilis

Authors
  • Bange, Gert1
  • Bedrunka, Patricia1
  • 1 Philipps-University Marburg, Hans-Meerwein-Strasse 6, C07 , (Germany)
Type
Published Article
Journal
Biological Chemistry
Publisher
Walter de Gruyter GmbH
Publication Date
Sep 16, 2020
Volume
401
Issue
12
Pages
1307–1322
Identifiers
DOI: 10.1515/hsz-2020-0241
Source
De Gruyter
Keywords
License
Green

Abstract

The guanosine-based second messengers (p)ppGpp and c-di-GMP are key players of the physiological regulation of the Gram-positive model organism Bacillus subtilis. Their regulatory spectrum ranges from key metabolic processes over motility to biofilm formation. Here we review our mechanistic knowledge on their synthesis and degradation in response to environmental and stress signals as well as what is known on their cellular effectors and targets. Moreover, we discuss open questions and our gaps in knowledge on these two important second messengers.

Report this publication

Statistics

Seen <100 times