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A physiologically based pharmacokinetic model for strontium exposure in rat.

Authors
  • Pertinez, Henry
  • Chenel, Marylore
  • Aarons, Leon
Type
Published Article
Journal
Pharmaceutical Research
Publisher
Springer-Verlag
Publication Date
Jun 01, 2013
Volume
30
Issue
6
Pages
1536–1552
Identifiers
DOI: 10.1007/s11095-013-0991-x
PMID: 23543304
Source
Medline
License
Unknown

Abstract

The model describes Strontium exposure in a physiologically rationalized manner and has the potential for future uses in modelling the PK-PD of Strontium, and/or other bone seeking agents, and for scaling to model human Strontium bone exposure.

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