Affordable Access

Access to the full text

Physiologically Active Compounds Based on Membranotropic Cage Carriers–Derivatives of Adamantane and Polyhedral Boron Clusters (Review)

Authors
  • Avdeeva, V. V.1
  • Garaev, T. M.2
  • Malinina, E. A.1
  • Zhizhin, K. Yu.1
  • Kuznetsov, N. T.1
  • 1 Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia , Moscow (Russia)
  • 2 Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow, 123098, Russia , Moscow (Russia)
Type
Published Article
Journal
Russian Journal of Inorganic Chemistry
Publisher
Pleiades Publishing
Publication Date
Jan 01, 2022
Volume
67
Issue
1
Pages
28–47
Identifiers
DOI: 10.1134/S0036023622010028
Source
Springer Nature
Keywords
Disciplines
  • Synthesis and Properties of Inorganic Compounds
License
Yellow

Abstract

AbstractData on compounds based on cage structures―boron clusters (polyhedral boron hydrides, carboranes, metallacarboranes) and compounds of the adamantane series, which possess physiological activity, have been generalized. The main emphasis is placed on the antiviral activity of the compounds. The mechanism of the possible action of the replication inhibitors of influenza A virus strains is considered, the molecular model of viroporin inhibitors is discussed. The proposed model consists of a cage hydrophobic core that performs the function of a membranotropic carrier (a boron cluster or adamantane fragment), into which physiologically active functional groups are introduced. The relationship between the structure of the cage compound with the introduced substitute and the biologically active properties of this molecular structure has been analyzed.

Report this publication

Statistics

Seen <100 times