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Physiological role of adiponectin in different tissues: a review.

Authors
  • Esmaili, S1
  • Hemmati, M2
  • Karamian, M3
  • 1 Student Research Committee, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. , (Iran)
  • 2 Cardiovascular Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran. , (Iran)
  • 3 Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran. , (Iran)
Type
Published Article
Journal
Archives of physiology and biochemistry
Publication Date
Feb 01, 2020
Volume
126
Issue
1
Pages
67–73
Identifiers
DOI: 10.1080/13813455.2018.1493606
PMID: 30451000
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an important role in setting up the metabolism and improving the function of various organs. Adiponectin in the kidneys prevents degradation of the renal arteries, reduces protein excretion, and improves filtration. This role is accomplished by regulating anabolic pathways and reducing oxidative stress in the renal tissue. This hormone in the liver prevents the accumulation of fat and free radicals that cause damage to liver cells and tissue. This adipokine, by preventing inflammatory processes, oxidative stress, obesity and insulin resistance, improves vascular function and prevents the development of atherosclerosis. It seems that adiponectin can also be a therapeutic target for many metabolic diseases. This study aims to clarify the adipose tissue discharge. Here, the diverse physiological actions of adiponectin were reviewed to provide an overview of its therapeutic potential in different metabolic disorders.

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