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Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey.

Authors
  • Wang, Yu-Shin1
  • Li, Miao1
  • Tell, Lisa A2
  • Baynes, Ronald E3
  • Davis, Jennifer L4
  • Vickroy, Thomas W5
  • Riviere, Jim E1, 3
  • Lin, Zhoumeng1
  • 1 Institute of Computational Comparative Medicine (ICCM), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
  • 2 Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
  • 3 Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
  • 4 Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.
  • 5 Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Type
Published Article
Journal
Journal of veterinary pharmacology and therapeutics
Publication Date
Dec 02, 2020
Identifiers
DOI: 10.1111/jvp.12931
PMID: 33289178
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Physiologically based pharmacokinetic (PBPK) models are growing in popularity due to human food safety concerns and for estimating drug residue distribution and estimating withdrawal intervals for veterinary products originating from livestock species. This paper focuses on the physiological and anatomical data, including cardiac output, organ weight, and blood flow values, needed for PBPK modeling applications for avian species commonly consumed in the poultry market. Experimental and field studies from 1940 to 2019 for broiler chickens (1-70 days old, 40 g - 3.2 kg), laying hens (4-15 months old, 1.1-2.0 kg), and turkeys (1 day-14 months old, 60 g -12.7 kg) were searched systematically using PubMed, Google Scholar, ProQuest, and ScienceDirect for data collection in 2019 and 2020. Relevant data were extracted from the literature with mean and standard deviation (SD) being calculated and compiled in tables of relative organ weights (% of body weight) and relative blood flows (% of cardiac output). Trends of organ or tissue weight growth during different life stages were calculated when sufficient data were available. These compiled data sets facilitate future PBPK model development and applications, especially in estimating chemical residue concentrations in edible tissues to calculate food safety withdrawal intervals for poultry. © 2020 The Authors. Journal of Veterinary Pharmacology and Therapeutics published by John Wiley & Sons Ltd.

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