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Physiological functions of urea transporter B

Authors
  • Yu, Lanying1
  • Liu, Tiantian1
  • Fu, Shuang1
  • Li, Li1
  • Meng, Xiaoping1
  • Su, Xin1
  • Xie, Zhanfeng1
  • Ren, Jiayan1
  • Meng, Yan2
  • Lv, Xuejiao3
  • Du, Yanwei1
  • 1 Changchun University of Chinese Medicine, Changchun, 130117, People’s Republic of China , Changchun (China)
  • 2 Jilin University, Changchun, Jilin, 130021, People’s Republic of China , Jilin (China)
  • 3 the Second Affiliated Hospital of Jilin University, Changchun, Jilin, 130041, People’s Republic of China , Jilin (China)
Type
Published Article
Journal
Pflügers Archiv - European Journal of Physiology
Publisher
Springer-Verlag
Publication Date
Nov 22, 2019
Volume
471
Issue
11-12
Pages
1359–1368
Identifiers
DOI: 10.1007/s00424-019-02323-x
Source
Springer Nature
Keywords
License
Green

Abstract

Urea transporters (UTs) are membrane proteins in the urea transporter protein A (UT-A) and urea transporter protein B (UT-B) families. UT-B is mainly expressed in endothelial cell membrane of the renal medulla and in other tissues, including the brain, heart, pancreas, colon, bladder, bone marrow, and cochlea. UT-B is responsible for the maintenance of urea concentration, male reproductive function, blood pressure, bone metabolism, and brain astrocyte and cardiac functions. Its deficiency and dysfunction contribute to the pathogenesis of many diseases. Actually, UT-B deficiency increases the sensitivity of bladder epithelial cells to apoptosis triggers in mice and UT-B-null mice develop II-III atrioventricular block and depression. The expression of UT-B in the rumen of cow and sheep may participate in digestive function. However, there is no systemic review to discuss the UT-B functions. Here, we update research approaches to understanding the functions of UT-B.

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