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Physiological endpoints in daphnid acute toxicity tests.

Authors
  • Bownik, Adam1
  • 1 Department of Hydrobiology and Protection of Ecosystems, University of Life Sciences in Lublin, Dobrzańskiego 37, 20-262 Lublin, Poland. Electronic address: [email protected] , (Poland)
Type
Published Article
Journal
The Science of the total environment
Publication Date
Jan 15, 2020
Volume
700
Pages
134400–134400
Identifiers
DOI: 10.1016/j.scitotenv.2019.134400
PMID: 31689654
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Daphnids are freshwater crustaceans used in toxicity tests. Although lethality and immobilisation are the most commonly used endpoints in those tests, more sensitive parameters are required for determination of sublethal acute effects of toxicants. The use of various physiological endpoints in daphnids is considered as a low-cost and simple alternative that meets the 3R's rule (Replacement, Reduction, Refinement) criteria. However, currently there is no review-based evaluation of their applicability in toxicity testing. This paper presents the results on the most commonly determined physiological parameters of Daphnia in ecotoxicological studies and human drug testing, such as feeding activity, thoracic limb movement, heart rate, cardiac area, respiratory activity, compound eye, mandible movements and post-abdominal claw contractions. Furthermore, their applicability as promising endpoints in the assessment of water quality or drug testing is discussed. Copyright © 2019 Elsevier B.V. All rights reserved.

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