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Physiological complexity, aging, and the path to frailty.

Authors
Type
Published Article
Journal
Science of aging knowledge environment : SAGE KE
Publication Date
Volume
2004
Issue
16
Identifiers
PMID: 15103055
Source
Medline

Abstract

Healthy physiological processes require the complex interaction of multiple control systems operating over multiple time scales. The output of these processes (for example, heart rate, blood pressure, hormonal rhythms, or postural sway) demonstrates complex variability that can be quantified using the concept of fractals, derived from the field of nonlinear dynamics. Complex physiological dynamics enable an organism to rapidly respond to the internal and external perturbations of everyday life. Aging and disease are associated with a loss of complexity in the dynamics of many physiological systems. This loss of complexity may reduce the ability to adapt to stress and lead to the syndrome of frailty.

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